Glitch Reading: [Re]Mediation and the Protocols of Reading

In this paper, I outline a methodology for reading poetic works that operate between media environments, noting the subtle shifts and failures that mark the material changes. The space between mediums and processes of remediation produce residue from the various material substrates and protocols of reading that adhere to works moving through networks. The attention to the residue can be understood as glitches, which proliferate the possibilities of reading and reveal the construction of imbricated reading environments. This is a practice I want to consider through the framework of glitch reading. Drawing on Rosa Menkman\u27s theorization of glitches and Tan Lin\u27s considerations of reading environments, I develop an understand of glitch reading as a critical and creative project that considers the proliferation of activities that constitute reading. In many ways this is a response to Alexander Galloway’s call for “new methodologies of scanning, playing, sampling, parsing, and recombining” as critical methods. In continuing to consider the mediation and between status of the glitch, these practices trouble the boundaries between critical and creative, material and immaterial, chaotic noise and apophenic messages. Glitch reading is a practice of reading processes of mediation, reading ruptures, distortions, and absences. It is a rupture in the protocols of reading, exposing the structures of reading and the way in which they can be expanded or further developed through remediation. In this sense, glitch reading becomes a way to understand reading as a process of disparate activities that fabricate a fluid structure that is designated as reading. It also includes processes that are often excluded from the structure of reading, what Tan Lin refers to as practices of non-reading. Attending to the glitch as a moment that exposes the material substrates that fabricate seamless environments, alternative forms of reading can proliferate and provide a glimpse into larger networks of relationality. By looking to works of art and poetics, and actually attempting to read the glitches, new possibilities in the regimes of reading become available. To read the glitch creates a way to reimagine and reconsider the networks of relations between humans and their technologies

Fluency Assistance Device

Currently about 1% of the world population (~70 million people) have a stutter considered a fluency disorder. Some fluency assistance devices are available for this population, but most are highly expensive or unreliable. Fluency Assistance Device (FAD) seeks to assist a niche community of these individuals for whom therapy has been unsuccessful but are currently depending on a device originally known as the Edinburgh Masker. FAD aims to redesign the masker to be more comfortable for the end user. FAD is developing versions 1.1 and 2.0 of the improved masker. Version 1.1 will update the original masker circuitry with surface mount devices. This will allow a slimmer circuitry enclosure, and enable upgrades of the original as requested. Version 2.0 will use Bluetooth technology and a microcontroller to achieve masker functionality with software code. FAD is now finalizing Version 1.1 and beginning Version 2.0.https://mosaic.messiah.edu/engr2020/1008/thumbnail.jp

A Low-Cost Egg Incubator to Provide Zambian Churches with Income and Food Security

Partnering with Brethren in Christ (BIC) Church in Zambia, the Egg Incubator Team is seeking to help provide a source of income for the growing churches in Choma, Zambia. They will accomplish this by designing and building a high-quality, low-cost egg incubator fabricated from local parts and cheap internationally available parts for The Nahumba Mission, in Choma, Zambia. The team’s design will provide the means for the Mission to hatch and sell chickens to provide both food security and a sustainable supplemental income. With the specifications to maintain temperature, humidity and constant ventilation, the team selected heating and humidity concepts for their incubator series. The team completed both mechanical and electrical designs for the setter and hatcher. In preparation for testing the incubator design with fertilized eggs, the team has also produced an incubation and hatching plan and achieved IACUC approval. Currently, the team is in the prototyping phase, while simultaneously monitoring the temperature and humidity in an existing incubator setter design. Once the team finishes their hatcher prototype and verifies that the temperature and humidity specifications are met, they will be ready to test designs using fertilized chicken eggs.https://mosaic.messiah.edu/engr2021/1020/thumbnail.jp

Prior infection with influenza virus but not vaccination leaves a long-term immunological imprint that intensifies the protective efficacy of antigenically drifted vaccine strains

AbstractThe role of pre-existing immunity for influenza vaccine responses is of great importance for public health, and thus has been studied in various contexts, yet the impact of differential priming on vaccine responses in the midst of antigenic drift remains to be elucidated. To address this with antigenically related viruses, mice were first primed by either infection or immunization with A/Puerto Rico/8/34 (PR8) virus, then immunized with whole-inactivated A/Fort Monmouth/1/47 (FM1) virus. The ensuing vaccine responses and the protective efficacy of FM1 were superior in PR8 infection-primed mice compared to PR8 immunization-primed or unprimed mice. Increased FM1-specific Ab responses of PR8 infection-primed mice also broadened cross-reactivity against contemporary as well as antigenically more drifted strains. Further, prior infection heightened the protective efficacy of antigenically distant strains, such as A/Brisbane/59/2006 infection followed by immunization with split pandemic H1N1 vaccine (A/California/07/2009). Therefore, influenza infection is a significant priming event that intensifies future vaccine responses against drift strains

Effects of an immersive psychosocial training program on depression and well-being: A randomized clinical trial.

Psychiatry stands to benefit from brief non-pharmacological treatments that effectively reduce depressive symptoms. To address this need, we conducted a single-blind randomized clinical trial assessing how a 6-day immersive psychosocial training program, followed by 10-min daily psychosocial exercises for 30 days, improves depressive symptoms. Forty-five adults were block-randomized by depression score to two arms: (a) the immersive psychosocial training program and 10-min daily exercise group (36 days total; total n = 23; depressed at baseline n = 14); or (b) a gratitude journaling control group (36 days total; total n = 22; depressed at baseline n = 13). The self-report PHQ-9 was used to assess depression levels in both groups at three time points: baseline, study week one, and study week six. Depression severity improved over time, with a significantly greater reduction in the psychosocial training program group (-82.7%) vs. the control group (-23%), p = 0.02 for baseline vs. week six. The effect size for this reduction in depression symptoms was large for the intervention group (d = -1.3; 95% CI, -2.07, -0.45; p < 0.001) and small for the control group (d = -0.3; 95% CI, -0.68, 0.03; p = 0.22). Seventy-nine percent (11/14) of depressed participants in the intervention condition were in remission (PHQ-9 ≤ 4) by week one and 100% (14/14) were in remission at week six. Secondary measures of anxiety, stress, loneliness, and well-being also improved by 15-80% in the intervention group (vs. 0-34% in the control group), ps < 0.05. Overall, this brief, immersive psychosocial training program rapidly and substantially improved depression levels and several related secondary outcomes, suggesting that immersive interventions may be useful for reducing depressive symptoms and enhancing well-being

Phytoplankton Supplementation Lowers Muscle Damage and Sustains Performance across Repeated Exercise Bouts in Humans and Improves Antioxidant Capacity in a Mechanistic Animal

The purpose of this study was to investigate the impact of antioxidant-rich marine phytoplankton supplementation (Oceanix, OCX) on performance and muscle damage following a cross-training event in endurance-trained subjects. Additionally, an animal model was carried out to assess the effects of varying dosages of OCX, with exercise, on intramuscular antioxidant capacity. Methods: In the human trial, endurance-trained subjects (average running distance = 29.5 ± 2.6 miles × week−1) were randomly divided into placebo (PLA) and OCX (25 mg) conditions for 14 days. The subjects were pre-tested on a one-mile uphill run, maximal isometric strength, countermovement jump (CMJ) and squat jump (SJ) power, and for muscle damage (creatine kinase (CK)). On Day 12, the subjects underwent a strenuous cross-training event. Measures were reassessed on Day 13 and 14 (24 h and 48 h Post event). In the animal model, Wistar rats were divided into four groups (n = 7): (i) Control (no exercise and placebo (CON)), (ii) Exercise (E), (iii) Exercise + OCX 1 (Oceanix, 2.55 mg/kg/day, (iv) Exercise + OCX 2 (5.1 mg/kg/day). The rats performed treadmill exercise five days a week for 6 weeks. Intramuscular antioxidant capacity (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px)) and muscle damage (CK and myoglobin (MYOB) were collected. The data were analyzed using repeated measures ANOVA and t-test for select variables. The alpha value was set at p < 0.05. Results: For the human trial, SJ power lowered in PLA relative to OCX at 24 h Post (−15%, p < 0.05). Decrements in isometric strength from Pre to 48 h Post were greater in the PLA group (−12%, p < 0.05) than in the OCX. Serum CK levels were greater in the PLA compared to the OCX (+14%, p < 0.05). For the animal trial, the intramuscular antioxidant capacity was increased in a general dose-dependent manner (E + Oc2 > E + Oc1 > E > CON). Additionally, CK and MYOB were lower in supplemented compared to E alone. Conclusions: Phytoplankton supplementation (Oceanix) sustains performance and lowers muscle damage across repeated exercise bouts. The ingredient appears to operate through an elevating oxidative capacity in skeletal muscle

Erratum: Sharp et al. Phytoplankton Supplementation Lowers Muscle Damage and Sustains Performance across Repeated Exercise Bouts in Humans and Improves Antioxidant Capacity in a Mechanistic Animal. <i>Nutrients</i> 2020, <i>12</i>, 1990

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Impact of tumor grade on pancreatic cancer prognosis: validation of a novel TNMG staging system.

BackgroundPancreatic ductal adenocarcinoma (PDAC) patients demonstrate highly variable survival within each stage of the American Joint Committee on Cancer (AJCC) staging system. We hypothesize that tumor grade is partly responsible for this variation. Recently our group developed a novel tumor, node, metastasis, grade (TNMG) classification system utilizing Surveillance Epidemiology and End Results (SEER) data in which the presence of high tumor grade results in advancement to the next higher AJCC stage. This study's objective was to validate this TNMG staging system utilizing single-institution data.MethodsAll patients with PDAC who underwent resection at UCLA between 1990 and 2009 were identified. Clinicopathologic data reviewed included age, sex, node status, tumor size, grade, and stage. Grade was redefined as a dichotomous variable. The impact of grade on survival was assessed by Cox regression analysis. Disease was restaged into the TNMG system and compared to the AJCC staging system.ResultsWe identified 256 patients who underwent resection for PDAC. Patients with low-grade tumors experienced a 13-month improvement in median survival compared to those with high-grade tumors. On multivariate analysis, tumor grade was the strongest predictor of survival with a hazard ratio of 2.02 (p = 0.0005). Restaging disease according to the novel TNMG staging system resulted in improved survival discrimination between stages compared to the current AJCC system.ConclusionsWe were able to demonstrate that grade is one of the strongest independent prognostic factors in PDAC. Restaging with our novel TNMG system demonstrated improved prognostication. This system offers an effective and convenient way of adding grade to the current AJCC staging system